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Late Show host David Letterman said goodbye Wednesday night with his trademark self-deprecating sarcasm. He left as he had arrived: with a hilarious show made on his own terms.

As the nation's opioid abuse problem soars, so do health problems associated with drug use like hepatitis C, which is placing a major burden on Alaska's Medicaid program.

A growing number of food videos aim to trigger ASMR — Autonomous Sensory Meridian Response, or pleasing sensations in the brains of some viewers — by focusing on sounds like chopping and stirring.

In southeast Alaska, the commercial king salmon fishing season has been shut down a month early, because the number of wild salmon returning to rivers to spawn is at an all-time low.

As President Donald Trump crosses the 100-day marker this weekend, photographer Gabriella Demczuk explores some of the major events that have transpired in the White House and on Capitol Hill.

The livelihoods of farmers and ranchers are intimately tied to weather and the environment. But they may no longer be able to depend on government research to help them adapt to climate change.

U.S. officials were slow to provide details about the agreements announced during Trump's trip abroad. Many of the deals were nonbinding — others had been in the works since Obama's administration.

The Federal Emergency Management Agency expects 450,000 people to seek help — including over 30,000 needing shelter. But as floodwaters rise, those aren't the only numbers defining the rescue efforts.

Sarah Palin is backing the House speaker's GOP primary challenger after Ryan declined to endorse Donald Trump. But primary upsets remain rare and hard to orchestrate.

Retaliatory tariffs on dairy may put dairy farmers in Wisconsin, a state won by Donald Trump in 2016, up for political grabs in this year's midterm elections.