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The 4-decades long effort to create an AIDS vaccine suffered a blow with news that a vaccine in a late stage trial was discontinued because results showed it to be ineffective. What are the obstacles?

An accused drug dealer has turned the tables and helped prosecutors convict his defense lawyer of manufacturing evidence to help his case. The hard-nosed strategy is raising questions about whether the Justice Department is chilling the relationship between a defendant and his lawyer.

The former governor of New Jersey — and onetime Trump ally — announced the end of his campaign Wednesday, just days before the first-in-the-nation Iowa caucuses.

After expanding state Medicaid programs to cover people in the country without legal status, Democrats are considering changes that would reduce immigrant access.

The Federal Reserve raised its benchmark interest rate by a quarter percentage-point in an effort to curb high inflation. Some had called for the Fed to wait after two recent bank failures.

The Federal Reserve raised its benchmark interest rate by a quarter percentage-point in an effort to curb high inflation. Some had called for the Fed to wait after two recent bank failures.

New York Times journalist Eric Schmitt says the president's threats against Iran and his recent purge at the Pentagon, in which he ousted his secretary of defense, could undermine national security.

The California governor, late Apple co-founder and state general attorney are among the people the San Francisco transit agency owes some $6.1 million in overpayments for parking citations.

There are at least three winning tickets for the Powerball's record $1.6 billion jackpot. The six winning numbers were 8, 27, 34, 4, 19 and the Powerball, 10.

The three Syrian children, aged 5 and 6, were near death from dehydration when they were discovered by police in the back of a minivan on Saturday.